Lead Pb 212 pentixather

{
  "id": "MLC-T-ONC-014729",
  "term": "Lead Pb 212 pentixather",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of pentixather, a chemokine receptor C-X-C chemokine receptor type 4 (CXCR4)-targeting ligand, conjugated to the alpha-emitting radioisotope lead Pb 212, with potential antineoplastic activity. Upon administration, lead Pb 212 pentixather targets and binds to CXCR4-expressing cancer cells. This allows for the specific delivery of a cytotoxic dose of alpha radiation to CXCR4-expressing cancer cells. CXCR4, a marker of poorly differentiated cells, is overexpressed on various cancer cells, and plays a key role in tumor growth, progression, invasiveness and metastasis.",
  "synonyms": [
    "212Pb-pentixather",
    "lead 212-labeled pentixather",
    "212-lead pentixather",
    "lead Pb 212-pentixather"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lead-pb-212-pentixather/"
}