Lead Pb 203 VMT-a-NET

{
  "id": "MLC-T-ONC-014726",
  "term": "Lead Pb 203 VMT-a-NET",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate consisting of the human somatostatin receptor subtype 2 (SSTR2)-targeting peptide and Tyr3-octreotide (TOC) analog VMT-a-NET, in which the N-terminus of TOC is conjugated, via polyethylene glycol (PEG) linkers (PEG2), to the cyclen-based lead-specific chelator PSC and labeled with the gamma-emitting radioisotope lead Pb 203, with potential imaging activity of neuroendocrine tumors (NETs) using single photon emission computed tomography (SPECT)/computed tomography (CT). Upon administration of lead Pb 203 VMT-a-NET, the peptide moiety specifically targets and binds to SSTR2, which is present on the cell membranes of many types of NETs. This allows for visualization of SSTR2-positive cells upon SPECT/CT imaging. SSTR2 is overexpressed on NETs and their metastases while most other normal tissues express low levels of SSTR2.",
  "synonyms": [
    "203Pb-PSC-PEG2-TOC",
    "203Pb-VMT-a-NET",
    "[203Pb]Pb-PSC-PEG-T",
    "[203Pb]PSC-PEG2-TOC",
    "[203Pb]VMT-alpha-NET",
    "lead Pb 203 PSC-PEG2-TOC"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lead-pb-203-vmt-a-net/"
}