lead Pb 203-VMT01

{
  "id": "MLC-T-ONC-014727",
  "term": "lead Pb 203-VMT01",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of the melanocyte-stimulating hormone receptor (MSHR; melanocortin-1 receptor; MC1R; melanin-activating peptide receptor; melanotropin receptor)-targeting peptide, VMT01, labeled with the radioisotope lead Pb 203, with potential imaging activity using single photon emission computed tomography (SPECT)/computed tomography (CT). Upon administration of lead Pb 203-VMT01, VMT01 targets and binds to MC1R-expressing tumor cells. Upon SPECT/CT imaging, MC1R-expressing tumor cells can be detected. MC1R, a G protein-coupled receptor expressed by melanocytes that binds to melanocortins, is involved in regulating mammalian skin and hair color. It is upregulated on the surface of metastatic melanoma cells.",
  "synonyms": [
    "203Pb-DOTA-VMT-MCR1",
    "[203Pb]-VMT01",
    "[203Pb]VMT01",
    "lead Pb 203-DOTA-VMT-MCR1"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lead-pb-203-vmt01/"
}