copper Cu 67 ucasareotide dasaroxetan

{
  "id": "MLC-T-ONC-012768",
  "term": "copper Cu 67 ucasareotide dasaroxetan",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate consisting of the tyrosine-containing somatostatin analog Tyr3-octreotate (TATE) conjugated with the bifunctional chelator 5-(8-methyl-3,6,10,13,16,19-hexaaza-bicyclo[6.6.6]icosan-1-ylamino)-5-oxopentanoic acid (MeCOSar) and radiolabeled with the beta-emitting radioisotope copper Cu 67, with potential antineoplastic activity. Upon administration, copper Cu 67 ucasareotide dasaroxetan binds to somatostatin receptors (SSTRs), with high affinity to type 2 SSTR, present on the cell membranes of many types of neuroendocrine tumor (NET) cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to SSTR-positive cells. TATE is an octreotide derivative in which phenylalanine at position 3 is substituted by tyrosine and position 8 threoninol is replaced with threonine. SSTRs have been shown to be present in large numbers on NET and their metastases, while most other normal tissues express low levels of SSTRs.",
  "abbreviation": "67Cu-SARTATE",
  "synonyms": [
    "67Cu-labelled MeCOSar-Tyr3-octreotate",
    "copper Cu 67-SARTATE",
    "Cu-67 SARTATE",
    "copper 67 SARTATE",
    "copper Cu 67 TATE",
    "67Cu-labeled MeCOSar-Tyr3-octreotate",
    "Copper Cu 67 Tyr3-octreotate",
    "ucasareotide dasaroxetan Cu-67"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/copper-cu-67-ucasareotide-dasaroxetan/"
}