Lutetium Lu 177-dotatate

{
  "id": "MLC-T-ONC-004994",
  "term": "Lutetium Lu 177-dotatate",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A radioactive drug used to treat adults and children aged 12 years and older with gastroenteropancreatic neuroendocrine tumors that are somatostatin receptor positive. It is also being studied in the treatment of other types of cancer. Lutetium Lu 177-dotatate binds to a protein called somatostatin receptor, which is found on some neuroendocrine tumor cells. Lutetium Lu 177-dotatate builds up in these cells and gives off radiation that may kill them. It is a type of radioconjugate and a type of somatostatin analog. Also called Lutathera.",
    "A radioconjugate consisting of the tyrosine-containing somatostatin analog Tyr3-octreotate (TATE) conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and radiolabeled with the beta-emitting radioisotope lutetium Lu 177, with potential imaging and antineoplastic activities. Lutetium Lu 177 dotatate binds to somatostatin receptors (SSTRs), with high affinity to type 2 SSTR, present on the cell membranes of many types of neuroendocrine tumor (NET) cells. Upon binding and internalization, this radioconjugate specifically delivers a cytotoxic dose of beta radiation to SSTR-positive cells. Tyr3-octreotate (TATE) is an octreotide derivative in which phenylalanine at position 3 is substituted by tyrosine and position 8 threoninol is replaced with threonine. SSTRs have been shown to be present in large numbers on NET and their metastases, while most other normal tissues express low levels of SSTRs."
  ],
  "abbreviation": "177 Lu-DOTA-TATE",
  "synonyms": [
    "Lutathera",
    "lutetium Lu 177-DOTATATE",
    "177 Lu-DOTA-Tyr3-octreotate",
    "lutetium oxodotreotide LU-177",
    "177Lu-DOTA0-Tyr3-Octreotate",
    "lutetium Lu 177 DOTA(0)-Tyr(3)-octreotate",
    "lutetium Lu 177-DOTA-Tyr3-octreotate"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lutetium-lu-177-dotatate/"
}