copper Cu 64 ucasareotide dasaroxetan

{
  "id": "MLC-T-ONC-012754",
  "term": "copper Cu 64 ucasareotide dasaroxetan",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate consisting of the tyrosine-containing somatostatin analog Tyr3-octreotate (TATE) conjugated with the bifunctional chelator 5-(8-methyl-3,6,10,13,16,19-hexaaza-bicyclo[6.6.6]icosan-1-ylamino)-5-oxopentanoic acid (MeCOSar) and labeled with the positron emission tomography (PET) tracer copper Cu 64, which may be used to image somatostatin receptor (SSTR)-expressing neuroendocrine tumors (NETs) upon PET. Upon administration of copper Cu 64 ucasareotide dasaroxetan, the TATE moiety targets and binds to SSTRs, with high affinity for type 2 SSTR, present on the cell membranes of many types of NETs. This allows for visualization of SSTR-positive tumor cells upon PET. TATE is an octreotide derivative in which phenylalanine at position 3 is substituted by tyrosine and position 8 threoninol is replaced with threonine. SSTRs have been shown to be present in large numbers on NETs and their metastases, while most other normal tissues express low levels of SSTRs.",
  "synonyms": [
    "64Cu-labeled MeCOSar-Tyr3-octreotate",
    "64Cu-SARTATE",
    "copper 64 SARTATE",
    "copper Cu 64-SARTATE",
    "Cu-64 SARTATE",
    "ucasareotide dasaroxetan Cu-64",
    "copper Cu 64-MeCOSar-Tyr3-octreotate"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/copper-cu-64-ucasareotide-dasaroxetan/"
}