copper Cu 64-DOTA-TLX592

{
  "id": "MLC-T-ONC-012762",
  "term": "copper Cu 64-DOTA-TLX592",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate containing an engineered monoclonal antibody targeting the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA), conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA), and labeled with the radioisotope copper Cu 64, with potential diagnostic properties upon positron emission tomography (PET) imaging. Upon administration of copper Cu 64-DOTA-TLX592, the monoclonal antibody moiety TLX592 targets and specifically binds to PSMA on tumor cells. Upon binding, the radioisotope moiety may be detected using PET, thereby allowing the imaging and quantification of PSMA-expressing tumor cells and the biodistribution of TLX592. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells.",
  "synonyms": [
    "64Cu-DOTA-TLX592",
    "64Cu-TLX592"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/copper-cu-64-dota-tlx592/"
}