copper Cu 67 SAR-bisPSMA

{
  "id": "MLC-T-ONC-012766",
  "term": "copper Cu 67 SAR-bisPSMA",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of two human prostate-specific membrane antigen (PSMA)-binding motifs linked to a sarcophagine (SAR)-based chelator and radiolabeled with the beta-emitting radioisotope copper Cu 67, with potential antineoplastic activity. Upon administration of copper Cu 67 SAR-bisPSMA, the PSMA-binding motifs target and bind to PSMA-expressing tumor cells, thereby delivering a cytotoxic dose of beta radiation to PSMA-expressing tumor cells. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells as well as a variety of other solid tumors.",
  "synonyms": [
    "67Cu SAR-bisPSMA",
    "67Cu-SAR-bisPSMA",
    "copper Cu 67-SAR-bisPSMA"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/copper-cu-67-sar-bispsma/"
}