indium In 111 anti-EGFR monoclonal antibody ABT-806

{
  "id": "MLC-T-ONC-014410",
  "term": "indium In 111 anti-EGFR monoclonal antibody ABT-806",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate composed of a humanized monoclonal antibody IgG1 directed against the epidermal growth factor receptor (EGFR) and labeled with the radioisotope indium In 111, with potential radioimaging activity. Indium In 111 anti-EGFR monoclonal antibody ABT-806 binds to a specific epitope of either wild-type or EGFR variant III mutant on tumor cells, thereby allowing imaging of EGFR-expressing tumor cells using gamma scintigraphy. ABT-806 is the humanized version derived from the predecessor chimeric monoclonal antibody 806. EGFR, a receptor tyrosine kinase overexpressed on the cell surfaces of many tumor cell types, plays a key role in tumor cell proliferation.",
  "abbreviation": "ABT-806i",
  "synonyms": [
    "Indium In 111 ABT-806"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indium-in-111-anti-egfr-monoclonal-antibody-abt-806/"
}