anti-EGFR monoclonal antibody ABT-806

{
  "id": "MLC-T-ONC-010592",
  "term": "anti-EGFR monoclonal antibody ABT-806",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody (MoAb) against human epidermal growth factor receptor (EGFR) with antineoplastic activity. MoAb ABT-806 targets the EGFR deletion variant, de2-7 EGFR as well as wild-type EGFR expressed in cells overexpressing the receptor, thereby preventing the activation and subsequent dimerization of the receptor; the decrease in receptor activation and dimerization result in an inhibition in signal transduction and anti-proliferative effects. This MoAb targets cells expressing aberrant EGFR, hence making it an ideal candidate for generation of radioisotope or toxin conjugates.",
  "abbreviation": "anti-EGFR MoAb ABT-806",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-egfr-monoclonal-antibody-abt-806/"
}