anti-EGFR monoclonal antibody CPGJ 602

{
  "id": "MLC-T-ONC-010593",
  "term": "anti-EGFR monoclonal antibody CPGJ 602",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant, human-mouse chimeric monoclonal antibody directed against the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Upon intravenous administration, anti-EGFR monoclonal antibody CPGJ 602 targets and binds to EGFR, which prevents receptor dimerization and activation. This leads to an inhibition of EGFR-dependent downstream pathways and EGFR-dependent tumor cell proliferation and metastasis. EGFR, a receptor tyrosine kinase, may be overexpressed on the surfaces of various tumor cell types.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-egfr-monoclonal-antibody-cpgj-602/"
}