interferon gamma-primed human bone marrow-derived mesenchymal stromal cells

{
  "id": "MLC-T-ONC-014475",
  "term": "interferon gamma-primed human bone marrow-derived mesenchymal stromal cells",
  "field": "Oncology and biomedicine",
  "definition": "Human bone marrow-derived mesenchymal stromal cells (MSCs) primed with interferon gamma (IFN-g), with potential immunomodulatory activity. Upon priming with IFN-g and the administration of IFN-g-primed human bone marrow-derived MSCs, IFN-g activates the IFN-g-Janus kinase (JAK)-signal transducer and activator of transcription 1 (STAT1) signaling pathway and induces indoleamine 2,3-dioxygenase (IDO) expression in MSCs. This promotes IDO activity and enhances the inhibition of T-cell proliferation mediated by MSCs. This may enhance MSC-mediated immunosuppression and prevent graft-versus-host disease (GvHD).",
  "synonyms": [
    "IFNγ-primed MSCs",
    "interferon gamma-primed human bone marrow-derived MSCs",
    "IFN-g-primed human bone marrow-derived MSCs",
    "IFN-g-primed MSCs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/interferon-gamma-primed-human-bone-marrow-derived-mesenchymal-stromal-cells/"
}