interferon gamma-1b

{
  "id": "MLC-T-ONC-014474",
  "term": "interferon gamma-1b",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant form of the endogenous cytokine interferon-gamma (IFN-gamma; IFNg), with a peptide length of 140 amino acids and modified with an N-terminal methionyl group, with potential immunomodulating and antineoplastic activities. Upon administration, IFNg-1b binds to IFNg cell surface receptors (IFNGRs), activates IFNg-stimulated signaling pathways, including the JAK-STAT pathway, and leads to the transcription of multiple IFNg-controlled genes, the expression of which may activate certain components of the immune system. IFNg activates natural killer (NK) cells, macrophages, and cytotoxic T lymphocytes (CTLs), stimulates antibody-dependent cellular cytotoxicity (ADCC) and induces the expression of major histocompatibility complex (MHC) molecules, which leads to an increase in antigen presentation, including tumor-associated antigens (TAAs), to the immune system, and modulates the expression of certain pro-inflammatory cytokines by antigen-presenting cells (APCs). Altogether, this increases tumor cell killing. IFNg-1b, a cell-signaling protein, plays a key role in the regulation and activation of the immune system.",
  "synonyms": [
    "N(sup 2)-L-methionyl-1-139-interferon G",
    "recombinant interferon gamma-1b"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/interferon-gamma-1b/"
}