Emapalumab-lzsg

{
  "id": "MLC-T-ONC-013319",
  "term": "Emapalumab-lzsg",
  "field": "Oncology and biomedicine",
  "definition": "A human monoclonal antibody against the cytokine interferon-gamma (IFN-gamma; IFNg), with potential immunomodulating activity. Upon administration, emapalumab binds to and neutralizes IFNg. This inhibits IFNg-mediated signaling pathways and suppresses the activation of the immune system. IFNg, a cell-signaling protein, plays a key role in the regulation and activation of the immune system; its upregulation is associated with certain auto-immune and auto-inflammatory diseases in which the immune system is abnormally activated.",
  "synonyms": [
    "anti-interferon gamma monoclonal antibody NI-0501",
    "anti-IFN gamma monoclonal antibody NI-0501",
    "anti-IFNg mAb NI-0501",
    "emapalumab"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/emapalumab-lzsg/"
}