Ad5-encoding IFNg SP-002

{
  "id": "MLC-T-ONC-009641",
  "term": "Ad5-encoding IFNg SP-002",
  "field": "Oncology and biomedicine",
  "definition": "A replication deficient adenovirus type 5 (Ad5) vector encoding for the cytokine human interferon gamma (IFNg; IFN-gamma), with potential antineoplastic and immunomodulating activities. Upon intratumoral administration, Ad5-encoding IFNg SP-002 expresses human IFNg, which binds to and activates the cell-surface IFN-gamma receptor and may stimulate an antiproliferative natural killer (NK) cell response against tumor cells and induce tumor cell apoptosis.",
  "synonyms": [
    "adenoviral vector Ad5-hIFNg SP-002",
    "adenovirus-5 vector-encoding human interferon gamma SP-002"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ad5-encoding-ifng-sp-002/"
}