recombinant adenovirus-interferon/Syn3

{
  "id": "MLC-T-ONC-016385",
  "term": "recombinant adenovirus-interferon/Syn3",
  "field": "Oncology and biomedicine",
  "definition": "A non-replicating recombinant adenovirus type 5 (Ad5)-vector encoding the gene for interferon alpha-2b (IFNα2b) and the gene transfer enhancement agent Syn 3, with potential antineoplastic activity. Upon intravesical administration, recombinant adenovirus-interferon with Syn3 transfects both cancerous and normal bladder cells, and the adenovirus secretes interferon (IFNα2b) into the bladder. IFN exerts a direct antitumor killing effect and a bystander effect, thereby killing adjacent, non-transfected cancerous bladder cells. Syn 3 enhances the ability of the adenoviral vector to transfect cells.",
  "synonyms": [
    "rAd-IFN/Syn3",
    "recombinant adenovirus-interferon with Syn3"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/recombinant-adenovirus-interferon-syn3/"
}