Ad5F35-LMP1/LMP2-transduced autologous dendritic cells

{
  "id": "MLC-T-ONC-009642",
  "term": "Ad5F35-LMP1/LMP2-transduced autologous dendritic cells",
  "field": "Oncology and biomedicine",
  "definition": "Autologous dendritic cells (DCs) transduced with the replication-deficient adenoviral vector Ad5F53 encoding the Epstein-Barr virus (EBV) transmembrane latent membrane proteins 1 and 2 (LMP1/LMP2) with potential immunostimulatory activity. Vaccination with Ad5F35-LMP1/LMP2-transduced autologous dendritic cells may stimulate a specific cytotoxic T-lymphocyte (CTL) response against LMP1- and LMP2-expressing tumor positive cells, resulting in tumor cell lysis and inhibition of tumor cell proliferation. LMP1 and LMP2 are expressed in various malignancies including nasopharyngeal cancer and EBV-positive Hodgkin disease.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ad5f35-lmp1-lmp2-transduced-autologous-dendritic-cells/"
}