LMP1-specific chimeric antigen receptor-expressing T lymphocytes

{
  "id": "MLC-T-ONC-014865",
  "term": "LMP1-specific chimeric antigen receptor-expressing T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of cytotoxic T lymphocytes (CTL) transfected with a chimeric antigen receptor (CAR) specifically recognizing the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1; LMP-1), with potential antineoplastic activity. Upon administration of the LMP1-specific CAR-expressing T lymphocytes to patients with LMP1-positive tumors, the CTLs specifically target and lyse tumor cells expressing LMP1, thereby inhibiting tumor cell proliferation. The tumor-associated antigen (TAA) LMP1 is expressed in various malignancies, including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma.",
  "synonyms": [
    "anti-LMP1 CAR T cells",
    "LMP1-CAR-T cells",
    "LMP1-CAR-CTLs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lmp1-specific-chimeric-antigen-receptor-expressing-t-lymphocytes/"
}