LMP2-specific T-cell receptor-transduced autologous T lymphocytes

{
  "id": "MLC-T-ONC-014870",
  "term": "LMP2-specific T-cell receptor-transduced autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a T-cell receptor (TCR) specific for the Epstein-Barr virus (EBV) latent membrane protein (LMP) 2, with potential immunomodulating and antineoplastic activities. Upon administration, LMP2-specific TCR-transduced autologous T lymphocytes recognize and bind to LMP2, which may promote cell death and inhibit the growth of tumor cells expressing LMP2. LMP2 is expressed in various EBV-associated malignancies.",
  "synonyms": [
    "LMP2 antigen-specific TCR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lmp2-specific-t-cell-receptor-transduced-autologous-t-lymphocytes/"
}