LMP2-specific IL-12-secreting T cell receptor-transduced T lymphocytes

{
  "id": "MLC-T-ONC-014869",
  "term": "LMP2-specific IL-12-secreting T cell receptor-transduced T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes that have been genetically modified to encode a T-cell receptor (TCR) specific for Epstein-Barr virus (EBV) latent membrane protein (LMP) 2, with potential antineoplastic activity. Upon administration, the LMP2-specific IL-12 secreting TCR-transduced T lymphocytes (TCR-T) recognize and bind to EBV LMP2, which may promote cell death and inhibit the growth of tumor cells expressing LMP2. In addition, IL-12 expression activates the immune system by promoting the secretion of interferon-gamma, activating natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death in LMP2-expressing tumor cells. As a tumor associated antigen (TAA), LMP2 is expressed in various EBV-associated malignancies including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma.",
  "synonyms": [
    "LMP2-specific IL-12-secreting TCR-transduced T lymphocytes",
    "LMP2-specific IL-12-secreting TCR-T cells",
    "LMP2-specific IL-12-secreting T cell Receptor-transduced T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lmp2-specific-il-12-secreting-t-cell-receptor-transduced-t-lymphocytes/"
}