EBV LMP-2A-specific autologous CD8+ T cells

{
  "id": "MLC-T-ONC-013202",
  "term": "EBV LMP-2A-specific autologous CD8+ T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous cytotoxic T lymphocytes (CTLs) that are specifically reactive to Epstein-Barr virus (EBV) latent membrane protein-2A (LMP-2A) and expressing the co-stimulatory domain 4-1BB (CD137), with potential antineoplastic activity. Upon administration of the EBV/LMP-2A-specific autologous CD8+ T cells to patients with EBV-positive tumors, these cells bind to and cause cell death in EBV-infected cells. This inhibits proliferation of EBV LMP-2A-expressing tumor cells. EBV LMP-2A is expressed in various malignancies and plays a key role in tumor cell proliferation and survival. 4-1BB, an inducible costimulatory member of the tumor-necrosis factor receptor (TNFR) family, is expressed on activated T cells. It activates additional CD8+ T cells, prevents activation-induced cell death of CD8+ T cells, and selectively induces T-helper 1 (Th1)-type cytokines such as interferon (IFN)-gamma and tumor-necrosis factor-alpha (TNF-alpha).",
  "abbreviation": "EBViNT",
  "synonyms": [
    "EBViNT cells",
    "EBV-induced T lymphocytes",
    "Epstein-Barr virus induced natural T cells",
    "Eutil autologous T lymphocytes",
    "EBViNT cell",
    "EBV-induced natural T cells",
    "EBV latent membrane protein-2a-specific Eutil autologous blood-derived T lymphocytes",
    "EBV/LMP-2A-specific CD8 T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ebv-lmp-2a-specific-autologous-cd8-plus-t-cells/"
}