poly-gamma glutamic acid

{
  "id": "MLC-T-ONC-016160",
  "term": "poly-gamma glutamic acid",
  "field": "Oncology and biomedicine",
  "definition": "A water-soluble and biodegradable polymer naturally synthesized by various strains of Bacillus and composed of D- and L-glutamic acid polymerized via gamma-amide linkages, with potential antineoplastic activity. Upon administration, poly-gamma glutamic acid may augment the immune response by increasing the production of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) and inducing the activation of macrophage and natural killer (NK) cells. In addition to its tumor control properties, IFN-gamma is a major mediator of innate and adaptive immunity against viral and intracellular bacterial infections. TNF-alpha is a cytokine involved in systemic inflammation, which is capable of inducing apoptotic cell death and exhibits anti-tumoral effects.",
  "synonyms": [
    "gamma-polyglutamic Acid",
    "gamma-PGA",
    "poly-gamma-glutamate"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/poly-gamma-glutamic-acid/"
}