Adalimumab

{
  "id": "MLC-T-ONC-009650",
  "term": "Adalimumab",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant, human IgG1 monoclonal antibody directed against tumor necrosis factor-alpha (TNF-alpha), with immunomodulating activity. Upon administration, adalimumab binds to TNF-alpha, thereby preventing its binding to the p55 and p75 TNF cell surface receptors and inhibiting TNF-mediated immune responses. TNF-alpha, a pro-inflammatory cytokine, is upregulated in various autoimmune diseases.",
  "synonyms": [
    "adalimumab biosimilar ABP 501"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adalimumab/"
}