CNGRC peptide-TNF alpha conjugate

{
  "id": "MLC-T-ONC-012686",
  "term": "CNGRC peptide-TNF alpha conjugate",
  "field": "Oncology and biomedicine",
  "definition": "A cytokine-peptide conjugate composed of the cytokine tumor necrosis factor alpha (TNF-alpha) chemically linked to the peptide CNGRC. The peptide moiety CNGRC, a ligand for the membrane-bound metalloprotease CD13, binds to endothelial cells of the angiogenic vasculature that express CD13 (also known as aminopeptidase N); subsequently, the TNF-alpha moiety induces apoptosis in endothelial cells expressing CD13, thereby inhibiting tumor-associated angiogenesis.",
  "abbreviation": "NGR-TNF",
  "synonyms": [
    "CNGRC peptide-tumor necrosis factor alpha conjugate",
    "tumor vasculature-targeted tumor necrosis factor alpha"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cngrc-peptide-tnf-alpha-conjugate/"
}