allogeneic skin-derived ABCB5-positive MSCs allo-APZ2-OTS

{
  "id": "MLC-T-ONC-009944",
  "term": "allogeneic skin-derived ABCB5-positive MSCs allo-APZ2-OTS",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of off-the-shelf (OTS) allogeneic human dermal ex-vivo expanded mesenchymal stromal cells (MSCs) expressing the ATP-binding cassette (ABC) efflux transporter, subfamily B, member 5 (ABCB5) that can potentially be used in the treatment of various skin-related and systemic inflammatory and degenerative conditions, such as recessive dystrophic epidermolysis bullosa (RDEB). Upon administration of the allo-APZ2-OTS, the MSCs are able to differentiate into several lineages, provide immunomodulatory activity, interact with various immune cells, such as macrophages, neutrophils and regulatory T cells (Tregs), and are able to secrete various anti-inflammatory mediators and pro-angiogenic molecules. Altogether, allo-APZ2-OTS may contribute to inflammation control and tissue repair.",
  "synonyms": [
    "allogeneic skin-derived ABCB5-positive mesenchymal stem cells allo-APZ2-OTS"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-skin-derived-abcb5-positive-mscs-allo-apz2-ots/"
}