Incomplete penetrance

{
  "id": "MLC-T-ONC-004265",
  "term": "Incomplete penetrance",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A term that describes when some people with a disease-causing mutation (change) in a gene develop the disease while others don’t. For example, certain gene mutations cause cancer, but because of incomplete penetrance, not everyone who has the mutation will develop cancer. Currently, there is no way to know which people who have a cancer-causing gene mutation will develop cancer. Also called reduced penetrance.",
    "Penetrance refers to the likelihood that a clinical condition will occur when a particular genotype is present. A condition is said to show incomplete penetrance when some individuals who carry the pathogenic variant express the associated trait while others do not. Also called reduced penetrance."
  ],
  "synonyms": [
    "reduced penetrance"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "NCI Dictionary of Genetics Terms"
  ],
  "url": "https://mlchart.com/terminology/oncology/incomplete-penetrance/"
}