Imatinib mesylate

{
  "id": "MLC-T-ONC-004180",
  "term": "Imatinib mesylate",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat certain types of leukemia and other blood cancers, gastrointestinal stromal tumors, skin tumors called dermatofibrosarcoma protuberans, and a certain type of a rare condition called systemic mastocytosis. It is also being studied in the treatment of other conditions and types of cancer. Imatinib mesylate blocks certain proteins made by the BCR::ABL1, PDGFR, or c-KIT oncogene, which may help keep cancer cells from growing and may kill them. Imatinib mesylate is a type of tyrosine kinase inhibitor. Also called Gleevec, Imkeldi, and STI571.",
    "The mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Inhibition of the bcr-abl TK results in decreased proliferation and enhanced apoptosis in malignant cells of Philadelphia-positive (Ph+) hematological malignancies such as CML and ALL; effects on c-kit TK activity inhibit mast-cell and cellular proliferation in those diseases overexpressing c-kit, such as mastocytosis and gastrointestinal stromal tumor (GIST)."
  ],
  "synonyms": [
    "Gleevec",
    "Imkeldi",
    "STI571"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/imatinib-mesylate/"
}