imalumab

{
  "id": "MLC-T-ONC-014370",
  "term": "imalumab",
  "field": "Oncology and biomedicine",
  "definition": "A human, recombinant monoclonal antibody (MoAb) against macrophage migration inhibitory factor (MIF), with potential immunomodulating, anti-inflammatory and antineoplastic activities. Upon intravenous administration, imalumab binds to MIF, blocking its activity and preventing the MIF-mediated secretion of certain cytokines, including interleukin-1 beta and tumor necrosis factor-alpha. This may lead to an inhibition of cancer cell proliferation in MIF-overexpressing tumor cells. MIF, a pro-inflammatory cytokine overexpressed in some cancers, plays a key role in inflammation, immune responses and cancer cell proliferation.",
  "synonyms": [
    "immunoglobulin G1-kappa, anti-(Homo sapiens MIF (macrophage migration inhibitory factor, glycosylation-inhibiting factor, GlIF, GIF)), Homo sapiens monoclonal antibody"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/imalumab/"
}