Brontictuzumab

{
  "id": "MLC-T-ONC-012131",
  "term": "Brontictuzumab",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody directed against the Notch-1 receptor with potential antineoplastic activity. Upon administration, brontictuzumab binds to Notch-1 on the cell surface, thereby inhibiting Notch-mediated signaling and tumor cell proliferation. Notch 1, a type 1 transmembrane protein belonging to the Notch family, functions as a receptor for membrane bound ligands and has various roles during development; dysregulated Notch signaling is associated with increased cell growth and chemoresistance in cancers.",
  "synonyms": [
    "anti-Notch1 monoclonal antibody OMP-52M51",
    "immunoglobulin G2-lambda, anti-(homo sapiens Notch1 (Notch 1, translocation-associated Notch-1, TAN-1,Tan1)), humanized monoclonal antibody"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/brontictuzumab/"
}