Tarextumab

{
  "id": "MLC-T-ONC-016985",
  "term": "Tarextumab",
  "field": "Oncology and biomedicine",
  "definition": "A monoclonal antibody directed against the Notch receptor with potential antineoplastic activity. Tarextumab binds to Notch on the cell surface, thereby inhibiting Notch-mediated signaling and gene transcription, which may impede tumor angiogenesis. Notch receptors are important for cell-cell communication, which involves gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. Dysregulated Notch signaling is implicated in many diseases including T-ALL (T-cell acute lymphoblastic leukemia), CADASIL (cerebral autosomal dominant arteriopathy with sub-cortical infarcts and leukoencephalopathy), MS (multiple sclerosis), and many other disease states.",
  "synonyms": [
    "anti-notch receptor monoclonal antibody OMP-59R5",
    "MoAb OMP-59R5"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tarextumab/"
}