Ifebemtinib

{
  "id": "MLC-T-ONC-014329",
  "term": "Ifebemtinib",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of the non-receptor, cytoplasmic tyrosine kinase protein tyrosine kinase 2 (focal adhesion kinase 1; FAK1; FAK: PTK2) with potential antineoplastic activity. Upon oral administration, ifebemtinib targets and inhibits, in an adenosine triphosphate (ATP)-competitive manner, PTK2. This prevents PTK2-mediated downstream signaling and inhibits migration, proliferation, invasion, and survival in PTK2-overexpressing tumor cells. The cytoplasmic tyrosine kinase PTK2, a signal transducer for integrins overexpressed in various tumor cell types, is involved in tumor cell invasion, migration and proliferation.",
  "synonyms": [
    "PTK2 inhibitor IN10018",
    "FAK1 inhibitor IN10018",
    "protein tyrosine kinase 2 inhibitor BI 853520",
    "protein tyrosine kinase 2 inhibitor IN10018"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ifebemtinib/"
}