IKKb-matured RNA-loaded autologous dendritic cells DCIKKb

{
  "id": "MLC-T-ONC-014340",
  "term": "IKKb-matured RNA-loaded autologous dendritic cells DCIKKb",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine consisting of autologous, monocyte-derived dendritic cells (DCs) that are matured with tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) beta, IL-6, prostaglandin E2 (PGE2) and IkB kinase b (IKKb), and loaded by electroporation with autologous total tumor RNA (TTRNA), RNA coding for tumor-associated antigens (TAAs) that may include gp100, tyrosinase, PRAME, MAGE-A3 and/or IDO, and RNA coding for driver mutations that may include GNAQ/GNA11Q209, R183, SF3B1R625, CYSLTR2L129Q and/or PLCB4D630, with potential immunostimulatory and antineoplastic activities. Upon administration, IKKb-matured, RNA-loaded autologous DCs DCIKKb may elicit a highly specific cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the TAAs and driver mutations encoded by the loaded RNA.",
  "abbreviation": "DCIKKb",
  "synonyms": [
    "IKKb-matured RNA-loaded autologous DCs DCIKKb"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ikkb-matured-rna-loaded-autologous-dendritic-cells-dcikkb/"
}