IKZF1/IKZF3 protein degrader GLB-002

{
  "id": "MLC-T-ONC-014341",
  "term": "IKZF1/IKZF3 protein degrader GLB-002",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable protein degrader of the transcription factors Ikaros (Ikaros family zinc finger protein 1; IKZF1) and Aiolos (Ikaros family zinc finger protein 3; IKZF3), with potential immunomodulating and antineoplastic activities. Upon oral administration, IKZF1/IKZF3 protein degrader GLB-002 modulates the E3 (ubiquitin) ligase and targets IKZF1 and IKZF3 for ubiquitination, and induces proteasome-mediated degradation of IKZF1 and IKZF3. This reduces the levels of these transcription factors, which are transcriptional repressors in T cells, and modulates the activity of the immune system. This also leads to the downregulation of other proteins, including interferon regulatory factor 4 (IRF4), which may result in apoptosis and the inhibition of tumor cell proliferation. IKZF1 and IKZF3 play a key role in B- and T-cell differentiation. IRF4, overexpressed in certain malignancies, is a transcription factor and key regulator of multiple genes controlling tumor cell survival.",
  "synonyms": [
    "Ikaros/Aiolos protein degrader GLB-002",
    "IKZF1/3 molecular glue protein degrader GLB-002",
    "IKZF1/3 protein degrader GLB-002"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ikzf1-ikzf3-protein-degrader-glb-002/"
}