Autologous bladder cell carcinoma RNAs/CD40L RNA electroporated autologous matured dendritic cells

{
  "id": "MLC-T-ONC-011518",
  "term": "Autologous bladder cell carcinoma RNAs/CD40L RNA electroporated autologous matured dendritic cells",
  "field": "Oncology and biomedicine",
  "definition": "A cell-based preparation in which autologous, mature dendritic cells (DCs) are electroporated with in vitro transcribed (IVT) RNAs encoding for a synthetic form of T-cell protein CD40 ligand (CD40L) and IVT RNA encoding for autologous tumor-associated antigens (TAAs) derived from patient-specific bladder cell carcinoma (BCC) cells, with potential immunostimulatory and antineoplastic activities. Upon electroporation into autologous DCs, the RNA is translated and processed. BCC-specific antigenic peptides are subsequently presented via major histocompatibility complex (MHC) Class I molecules on the DCs surface. When AGS-003-BLD is reintroduced to the patient, the MHC-presented peptides interact with and activate CD8-positive T cells, which elicits a highly specific cytotoxic T-cell (CTL) response against tumor cells expressing the patient-specific BCC TAAs. The signal cascade initiated by expression of the co-stimulatory molecule CD40L results in the secretion of the inflammatory cytokine IL-12, which further stimulates CTLs.",
  "synonyms": [
    "autologous DCs electroporated with autologous tumor-derived IVT RNAs/CD40L IVT RNA",
    "autologous DCs electroporated with autologous tumor-derived RNAs/CD40L RNA"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-bladder-cell-carcinoma-rnas-cd40l-rna-electroporated-autologous-cells/"
}