INS316

{
  "id": "MLC-T-ONC-004341",
  "term": "INS316",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the diagnosis of lung diseases, including lung cancer. It helps bring up a sample of mucus from deep in the lungs and improves the quality of the sample for testing. It is a type of nucleoside triphosphate.",
    "A short-acting, aerosolized uridine 5-triphosphate (UTP) solution used as a diagnostic aid for lung cancer. INS316 appears to improve sputum expectoration mediated through the P2Y2 receptor, a nucleotide receptor expressed in human airway epithelial cells and some other tissues. UTP binding to the P2Y2 receptor triggers signal transduction that leads to chloride ion secretion, thereby resulting in mucociliary clearance of airway."
  ],
  "expansions": [
    "uridine 5-triphosphate solution",
    "UTP solution"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ins316/"
}