indium In 111-ibritumomab tiuxetan

{
  "id": "MLC-T-ONC-004282",
  "term": "indium In 111-ibritumomab tiuxetan",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A radiolabeled monoclonal antibody used to find certain types of B-cell non-Hodgkin lymphoma. It is also being studied in the diagnosis of other types of B-cell tumors. Indium In 111-ibritumomab tiuxetan is made up of the monoclonal antibody ibritumomab plus the radioisotope indium In 111. It binds to a protein called CD20, which is found on B cells. A machine is used to find which cells in the body have taken up indium In 111-ibritumomab tiuxetan. Indium In 111-ibritumomab tiuxetan is a type of radioimmunoconjugate. Also called 111In-ibritumomab tiuxetan and 111In-Zevalin.",
    "A targeted radioimmunoconjugate composed of a murine monoclonal anti-CD20 antibody (ibritumomab) linked by a chelator (tiuxetan) to the imaging radioisotope indium-111. This radioimmunoconjugate binds to CD20-positive cells, permitting radioimmuno-localization of CD20-positive cell biodistribution."
  ],
  "synonyms": [
    "111In-ibritumomab tiuxetan",
    "111In-Zevalin"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indium-in-111-ibritumomab-tiuxetan/"
}