Idarubicin hydrochloride

{
  "id": "MLC-T-ONC-004120",
  "term": "Idarubicin hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used with other drugs to treat adults with acute myeloid leukemia. It is also being studied in the treatment of other types of cancer. Idarubicin hydrochloride blocks a certain enzyme needed for cell division and DNA repair and may kill cancer cells. It is a type of anthracycline antibiotic and a type of topoisomerase inhibitor. Also called 4-demethoxydaunorubicin and Idamycin PFS.",
    "The hydrochloride salt of the anthracycline antineoplastic antibiotic idarubicin. Idarubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds"
  ],
  "synonyms": [
    "4-demethoxydaunorubicin",
    "Idamycin PFS",
    "idarubicin HCl",
    "4-demethoxydaunomycin"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/idarubicin-hydrochloride/"
}