ifosfamide

{
  "id": "MLC-T-ONC-004142",
  "term": "ifosfamide",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used with other drugs to treat malignant testicular germ cell tumors that have already been treated with two other types of anticancer drugs. It is also being studied in the treatment of other types of cancer. Ifosfamide damages the cell’s DNA and may kill cancer cells. It is a type of alkylating agent and a type of antimetabolite. Also called Ifex.",
    "A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes."
  ],
  "abbreviation": "IFF",
  "synonyms": [
    "Ifex",
    "Naxamide",
    "iphosphamide",
    "isophosphamide",
    "Ifomide",
    "Iphosphamid",
    "Iso-Endoxan",
    "Isoendoxan"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ifosfamide/"
}