cyclophosphamide

{
  "id": "MLC-T-ONC-002218",
  "term": "cyclophosphamide",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat many types of cancer and a certain type of kidney disease in children. Cyclophosphamide damages the cell’s DNA and may kill cancer cells. It may also lower the body’s immune response. Cyclophosphamide is a type of alkylating agent. Also called CTX.",
    "A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death."
  ],
  "abbreviation": "CTX",
  "synonyms": [
    "CTX",
    "cyclophosphamide monohydrate",
    "neosar",
    "Genoxal",
    "CP monohydrate",
    "Ciclofosfamida",
    "ciclofosfamide",
    "Claphene",
    "cyclophospham",
    "cyclophosphamid monohydrate",
    "cyclophosphamidum",
    "cyclophosphan",
    "cyclophosphanum",
    "Cytophosphane",
    "Mitoxan",
    "Syklofosfamid"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cyclophosphamide/"
}