chlorambucil

{
  "id": "MLC-T-ONC-001687",
  "term": "chlorambucil",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat chronic lymphocytic leukemia, Hodgkin lymphoma, and certain types of non-Hodgkin lymphoma. It is also being studied in the treatment of other types of cancer. Chlorambucil damages the cell’s DNA and may kill cancer cells. It is a type of alkylating agent. Also called Leukeran.",
    "An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis."
  ],
  "abbreviation": "CLB",
  "synonyms": [
    "Leukeran",
    "Chlorbutin",
    "chlorambucilum",
    "chloraminophen",
    "chlorbutine",
    "chlorobutin",
    "chlorobutine",
    "Leukersan",
    "leukoran",
    "Lympholysin",
    "chlorbutinum",
    "chloroambucil",
    "phenylbutyric acid nitrogen mustard",
    "aminochlorambucil",
    "Ecloril",
    "Elcoril"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/chlorambucil/"
}