mechlorethamine hydrochloride

{
  "id": "MLC-T-ONC-005184",
  "term": "mechlorethamine hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used on the skin to treat stage I mycosis fungoides (a type of cutaneous T-cell lymphoma) in patients who have already been treated with other therapy. It is also being studied in the treatment of other types of cancer. Mechlorethamine hydrochloride damages the cell's DNA and may kill cancer cells. It is a type of alkylating agent. Also called mustine and Valchlor.",
    "The hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intemediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties."
  ],
  "synonyms": [
    "mustine",
    "Valchlor",
    "chlorethamine HCl",
    "chlorethamine hydrochloride",
    "chlorethazine hydrochloride",
    "chloromethine HCl",
    "chlormethine hydrochloride",
    "HN 2 hydrochloride",
    "mechlorethamine HCl",
    "mustargen HCl",
    "mustargen hydrochloride",
    "N-Lost"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mechlorethamine-hydrochloride/"
}