Icotinib hydrochloride

{
  "id": "MLC-T-ONC-014303",
  "term": "Icotinib hydrochloride",
  "field": "Oncology and biomedicine",
  "definition": "The hydrochloride salt form of icotinib, an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Icotinib selectively inhibits the wild-type and several mutated forms of EGFR tyrosine kinase. This may lead to an inhibition of EGFR-mediated signal transduction and may inhibit cancer cell proliferation. EGFR, a receptor tyrosine kinase, has been upregulated in a variety of cancer cell types.",
  "synonyms": [
    "icotinib HCl"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/icotinib-hydrochloride/"
}