carmustine

{
  "id": "MLC-T-ONC-001459",
  "term": "carmustine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used alone or with other drugs to treat certain types of brain tumors, Hodgkin lymphoma, and non-Hodgkin lymphoma and with prednisone to treat multiple myeloma. It is also being studied in the treatment of other types of cancer. Carmustine damages the cell's DNA and may kill cancer cells. It is a type of alkylating agent and a type of nitrosourea. Also called BCNU and BiCNU.",
    "An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily."
  ],
  "abbreviation": "BCNU",
  "synonyms": [
    "BCNU",
    "BiCNU",
    "bis-chloronitrosourea",
    "bis(chloroethyl) nitrosourea",
    "carmustin"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carmustine/"
}