lomustine

{
  "id": "MLC-T-ONC-004920",
  "term": "lomustine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat brain tumors that have already been treated with surgery or radiation therapy and Hodgkin lymphoma that got worse after treatment with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Lomustine damages the cell's DNA and may kill cancer cells. It is a type of alkylating agent and a type of nitrosourea. Also called CCNU and Gleostine.",
    "A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier."
  ],
  "abbreviation": "CCNU",
  "synonyms": [
    "CCNU",
    "Gleostine",
    "Lomustinum"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/lomustine/"
}