Semustine

{
  "id": "MLC-T-ONC-007658",
  "term": "Semustine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance that has been studied in the treatment of some types of cancer. Semustine damages the cell’s DNA and may kill cancer cells. It is a type of alkylating agent and a type of nitrosourea.",
    "A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity."
  ],
  "abbreviation": "MeCCNU",
  "synonyms": [
    "CCNU, methyl-",
    "MCCNU",
    "methyl CCNU",
    "methyl-CCNU"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/semustine/"
}