Spiromustine

{
  "id": "MLC-T-ONC-016845",
  "term": "Spiromustine",
  "field": "Oncology and biomedicine",
  "definition": "A bifunctional nitrogen alkylating agent with antineoplastic activity and lipophilic properties. Containing a lipophilic hydantoin group that serves as a carrier to cross the blood brain barrier, spiromustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity.",
  "abbreviation": "SHM",
  "synonyms": [
    "spirohydantoin mustard"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/spiromustine/"
}