Canfosfamide hydrochloride

{
  "id": "MLC-T-ONC-012224",
  "term": "Canfosfamide hydrochloride",
  "field": "Oncology and biomedicine",
  "definition": "The hydrochloride salt of a modified glutathione analogue with potential antineoplastic activity. Canfosfamide is selectively activated by glutathione S-transferase P1-1 into an alkylating metabolite that forms covalent linkages with nucleophilic centers in tumor cell DNA, which may induce a cellular stress response and cytotoxicity, and decrease tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/canfosfamide-hydrochloride/"
}