Cannabidiol

{
  "id": "MLC-T-ONC-001379",
  "term": "Cannabidiol",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A chemical that comes from the hemp (Cannabis sativa) plant. Cannabidiol contains very low levels of delta-9-THC (the main chemical that causes the “high” of marijuana). It may help relieve pain, lower inflammation, and reduce anxiety without causing the mind-altering effects of marijuana. Cannabidiol comes in many forms, including oils, extracts, capsules, and patches. One specific form has been approved in the United States as a drug to treat seizures in certain people. Cannabidiol is also being studied in the treatment of symptoms or side effects caused by cancer and cancer treatment. It is a type of cannabinoid. Also called CBD.",
    "A phytocannabinoid derived from Cannabis species, which is devoid of psychoactive activity, with analgesic, anti-inflammatory, antineoplastic and chemopreventive activities. Upon administration, cannabidiol (CBD) exerts its anti-proliferative, anti-angiogenic and pro-apoptotic activity through various mechanisms, which likely do not involve signaling by cannabinoid receptor 1 (CB1), CB2, or vanilloid receptor 1. CBD stimulates endoplasmic reticulum (ER) stress and inhibits AKT/mTOR signaling, thereby activating autophagy and promoting apoptosis. In addition, CBD enhances the generation of reactive oxygen species (ROS), which further enhances apoptosis. This agent also upregulates the expression of intercellular adhesion molecule 1 (ICAM-1) and tissue inhibitor of matrix metalloproteinases-1 (TIMP1) and decreases the expression of inhibitor of DNA binding 1 (ID-1). This inhibits cancer cell invasiveness and metastasis. CBD may also activate the transient receptor potential vanilloid type 2 (TRPV2), which may increase the uptake of various cytotoxic agents in cancer cells. The analgesic effect of CBD is mediated through the binding of this agent to and activation of CB1."
  ],
  "abbreviation": "CBD",
  "synonyms": [
    "CBD",
    "CBD oil"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cannabidiol/"
}