carmustine implant

{
  "id": "MLC-T-ONC-001460",
  "term": "carmustine implant",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used with surgery and radiation therapy to treat high-grade glioma that has not already been treated and with surgery to treat glioblastoma multiforme that has recurred (come back). Carmustine implant is a form of carmustine contained in a wafer. The wafer has a coating that dissolves slowly and releases carmustine directly into the area where the brain tumor was removed. This form may have fewer side effects and work better than other forms of carmustine. Carmustine implant is a type of alkylating agent and a type of nitrosourea. Also called Gliadel Wafer and polifeprosan 20 carmustine implant.",
    "A synthetic, biodegradable wafer containing the agent carmustine with antineoplastic activity. Used to deliver drug directly into a brain tumor site and typically implanted post-surgically, the wafer is made of a biodegradable poly-anhydride copolymer and contains the nitrosourea carmustine. As an antineoplastic nitrosourea, carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. Carmustine also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily."
  ],
  "synonyms": [
    "Gliadel Wafer",
    "polifeprosan 20 carmustine implant",
    "polifeprosan 20 with carmustine implant",
    "BCNU wafer",
    "carmustine copolymer",
    "carmustine wafer",
    "carmustine wafers"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/carmustine-implant/"
}