imaging agent QRH-882260 heptapeptide

{
  "id": "MLC-T-ONC-014369",
  "term": "imaging agent QRH-882260 heptapeptide",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable fluorescent imaging agent composed of the near-infrared (NIR) fluorophore cyanine 5 (Cy5) linked to a seven-amino acid long peptide that specifically binds to the tumor-associated antigen (TAA) epithelial growth factor receptor (epidermal growth factor receptor; EGFR), that can potentially be used for the imaging of EGFR-expressing tumor cells. Upon oral administration of the fluorescent imaging agent QRH-882260 heptapeptide, the peptide moiety selectively binds to EGFR expressed on tumor cells in the gastrointestinal (GI) tract. Upon fluorescence imaging, EGFR-expressing tumor cells can be visualized. EGFR, a member of the epidermal growth factor receptor family, is overexpressed on the surfaces of various tumors cells.",
  "synonyms": [
    "QRHKPRE-GGGSK-(Cy5)-NH2",
    "QRH-882260 Cy-5-labeled heptapeptide",
    "fluorescence peptide QRH-882260",
    "fluorescently-labeled peptide QRH-882260"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/imaging-agent-qrh-882260-heptapeptide/"
}